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Science Highlights & News
April 23, 2008
Researchers reveal structure of protein that repairs damage to cancer cells
A team of University of Chicago scientists has shown how two proteins locate and repair damaged genetic material inside cells. One protein detects and repairs damage in malignant cells that may result from a certain type of cancer therapy. In a paper published in the April 24 issue of the journal Nature, the team raised the possibility of designing a molecule that could interfere with the repair process, making cancer treatment more effective.
- Full story (lightsources.org) ›
- Cai-Guang Yang, Chengqi Yi, Erica M. Duguid, Christopher T. Sullivan, Xing Jian, Phoebe A. Rice, and Chuan He
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA
Nature, 452, 961-965 (24 April 2008) | doi:10.1038/nature06889
Facility News
April 18, 2008
BioCARS Open House Celebrates Upgrade
BioCARS 14-ID Upgrade Team
On April 18, 2008, BioCARS welcomed more than 60 people to an open house to celebrate the completion of the upgrade of beamline 14-ID and implementation of 100-picosecond time-resolved crystallography at BioCARS. The new configuration extends the time resolution available for the successful nanosecond time-resolved crystallography user program at BioCARS into the sub-ns time domain.
Speakers lauded a unique collaboration between BioCARS, NIH and APS staff that has established BioCARS as the premier facility worldwide for 100-ps time-resolved crystallography.
With the new 14-ID beamline optics and improved time resolution, many challenging new domains become accessible, including more complex biological molecules, irreversible reactions, and important biological processes such as cooperativity, signal transduction, and catalysis.