Facility News: BioCARS Hosts Workshop on Time-Resolved Crystallography
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- July 2008 -
Click for full-size movie*
BioCARS will host a workshop on time-resolved macromolecular crystallography on November 20-22, 2008. The workshop will provide hands-on training in designing and conducting time-resolved experiments, Laue data processing, and time-resolved data analysis. Workshop participants will also have an opportunity to discuss with experts in the field application of the technique to their own scientific projects. Applicants may also bring a crystal for data collection.
Proposed topics to be covered include the following:
- Laue diffraction technique: theory and practice
- Time-resolved experiments: principles and practice
- Reaction initiation in crystals:
- Light triggering: native and artificial photoreceptors, caged compounds
- Diffusion and flow cells
- Microspectrophotometry
- Laue data processing with the program Precognition
- Time-resolved data analysis:
- Principles and practice
- Singular Value Decomposition
The cost is $125 ($75 for students), and applications are due September 26. See the workshop web site for details.
BioCARS and this workshop are supported by NCRR/NIH grant 5 P41 RR007707 to The University of Chicago, Keith Moffat, PI. Additional support for the workshop is provided by the Center for Advanced Radiation Sources of The University of Chicago, which operates BioCARS.
*Movie: Time evolution of light-dark difference electron density maps during the photocycle of photoactive yellow protein, mutant E46Q. Anderson et al., Structure 12, 1039 (2004); Rajagopal et al., Structure 13, 55 (2005).